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KMID : 0360319950270040527
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 4 p.527 ~ p.534
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Prognostic Significance of c-erbB2, c-fos, p53, Proliferating Cell Nuclear Antigen(PCNA) and Epidermal Growth Factor(EGF)in Stage III Gastric Carcinomas
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이승도
백승언/이충한/허방/허만하
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Abstract
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To evaluate the prognostic significance of c-erbB2, c-fos, p53, PCNA and EGF in stage Ⅲgastric carcinoma, frequency of their expression was examined by immunohistochemical method in 206 cases of stage Ⅲgastric carcinomas with paraffin-embedded
tissue
specimens which were obtained surgically at the department of surgery, Kosin Medical College from 1984 to 1988. Survival rate and other clinicopathological parameters were analysed.
Expression rates of c-erbB2, c-fos, p53, PCNA and EGF were 46.1%, 43,7%, 62.1%, 65.0% and 35.9% respectively. Correlation of expression was found between EGF and c-fos, EGF and cerbB2, and c-erbB2 and c-fos respectively.
c-erbB2 expression was more frequently observed in intestinal type, well or moderately differentiated carcinomas than diffuse type, poorly differentiated or mucinous types(p<0.05). Similarly EGF expression rate was high in intestinal type and low
in
mucinous or signet ring cell types(p<0.05).
Five year survival rates of positive cases and negative cases were 27.4% and 23.9% in c-erbB2, 27.7% and 23.9% in c-fos, 24.0% and 27.8% in p53, 25.1% and 26.4% in PCNA and 20.5% and 28.9% in EGF respectively. There were no significant
differences
between positive cases and negative cases in survival rates.
When the above factors and conventional prognostic factors such as tumor depth(t3, t4), lymph node invasion(n-0, n1, n2), number of positive nodes(1-3, 4-6, 7-), Lauren's types, were entered simultaneously into the Cox regression model, number of
positive nodes, and EGF expression emerged as independent prognostic factors(p=0.0004, p=0.043 respectively).
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KEYWORD
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